Quinazolinone Derivatives as a Potential Class of Compounds in Malaria Drug Discovery

Pharmacological Evaluation of Quinazolinone Derivatives: A Review

In the field of medicinal chemistry, Quinazolinone is a heterocyclic compound having unique place which has medicinal uses as Anticancer, antihypertensive, antihyperlipidemic, antitubercular, CNS depressant, antioxidant, analgesic, antibacterial, anti-inflammatory and antimalarial activity. Quinazolinone based drugs have broadened scope in the field of medicine and Research. Some quinazolinone ...

Squalamine and its derivatives as potential antitubercular compounds.

Squalamine and its Derivatives as Potential Antitubercular Compounds

Karyotypic "state" as a potential determinant for anticancer drug discovery.

Cancer is a genetic disease caused by genomic instability. In many cancers, this instability is manifested by chromosomal reconfigurations and karyotypic complexity. These features are particular hallmarks of the epithelial cancers that are some of the malignancies most resistant to long term control by current chemotherapeutic agents. We have asked whether we could use karyotypic complexity an...

Mesua beccariana (Clusiaceae), a source of potential anti-cancer lead compounds in drug discovery.

An investigation on biologically active secondary metabolites from the stem bark of Mesua beccariana was carried out. A new cyclodione, mesuadione, along with several known constituents which are beccamarin, 2,5-dihydroxy-1,3,4-trimethoxy anthraquinone, 4-methoxy-1,3,5-trihydroxyanthraquinone, betulinic acid and stigmasterol were obtained from this ongoing research. Structures of these compound...